Production of fertile offspring from genetically infertile male mice
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چکیده
منابع مشابه
Production of fertile offspring from genetically infertile male mice.
A number of recessive autosomal genes cause male infertility. Male mice homozygous for the blind-sterile (bs/bs) and quaking-sterile (qk/qk) gene mutations are sterile, because they either do not produce any spermatozoa or produce only a few abnormal spermatozoa. Mice lacking the cyclic AMP responsive-element modulator gene are sterile due to failure of spermiogenesis. All these mice, however, ...
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Sertoli cells play a pivotal role in spermatogenesis through their interactions with germ cells. To set up a strategy for treating male infertility caused by Sertoli cell dysfunction, we developed a Sertoli cell gene transfer system by using an adenovirus vector, which maintained long-term transgene expression in the testes of infertile mice. Introduction of an adenovirus carrying the mouse Ste...
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The present report focuses on novel animal models of male infertility: genetically defined mice bearing single-gene mutations that induce infertility. The primary goal of our investigations was to identify the reproductive defects in these mutant mice. The phenotypic effects of the gene mutations were deciphered by comparing the mutant mice to their normal siblings. Initially testicular steroid...
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The presence of a complex population of mRNAs in human mature spermatozoa is well documented; among them, transcripts of aromatase and ERs (oestrogen receptors) have been described but their significance is not clear. Therefore, to clarify the role of this complex population of mRNAs in human ejaculated sperm, we have isolated on discontinuous density gradients two main fractions from the same ...
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PSYCHOLOGICAL DISTRESS IN INFERTILE AND FERTILE WOMEN Masoumeh Golestan Jahromi, Leili Mosalanejad, Fatemeh Ghavi Research and clinical center for infertility, Shahid Sadoghi University of Medical Sciences, Yazd, Iran. Assistant professor, mental health department, Research center for social determinants of health, Jahrom University of Medical Sciences, Jahrom, Iran. MSc of midwifery, Research ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0307832100